Nexium Control is a once daily tablet that provides continuous 24 hour protection from heartburn and acid reflux. Did you know that 7 out of 10 heartburn sufferers have frequent heartburn? Nexium Control is a tablet known as a PPI (proton pump inhibitor). It works by stopping the proton pump from releasing acid into the stomach. Nexium Control has been proven to provide significantly longer acid control compared to all other PPIs and is less extensively metabolised by the liver.