Glycoprep-C Lemon 70g

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ASCORBIC ACID and CITRIC ACID and POTASSIUM CHLORIDE and SODIUM CHLORIDE

Description

Glycoprep-C Lemon 70g

This product is a Pharmacist Only Medicine and requires pharmacist advice for us to send it to you. If you order this product, you will be required to call us within 48 hours on 03 9568 6677 to complete the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor’s prescription.

Each 70 or 210 g sachet contains macrogol 3350 (polyethylene glycol) 755.69 mg/g, sodium sulfate (anhydrous) 80.62 mg/g, sodium chloride 37.33 mg/g, potassium chloride 10.55 mg/g, citric acid 12.77 mg/g, ascorbic acid 85.16 mg/g, aspartame 5.11 mg/g and lemon flavour 12.77 mg/g.

Description

Macrogol 3350. Molecular formula: HOCH2 [CH2OCH2]m. CH2OH (where m equals 45 to 70).
Ascorbic acid. Molecular formula: C6H8O6. MW: 176.1. CAS: 50-81-7.
Sodium chloride. Molecular formula: NaCl. MW: 58.44. CAS: 7647-14-5.
Potassium chloride. Molecular formula: KCl. MW: 74.6. CAS: 7447-40-7.
Sodium sulfate. Molecular formula: Na2SO4. MW: 142.0. CAS: 7681-38-1.
Glycoprep-C. Glycoprep-C powder for solution is a white crystalline powder. When dissolved in water it produces a solution.

Actions

Electrolyte gastrointestinal lavage.

Pharmacology

Macrogol 3350 is not significantly absorbed and acts as an osmotic agent to induce a watery diarrhoea usually within one hour after commencing treatment and which normally removes the bowel contents by about four hours after commencing treatment.
The water and included electrolytes are iso-osmotic with normal intestinal contents and help to reduce or prevent electrolyte or water loss.

Indications

Bowel emptying and cleansing by means of total gastrointestinal tract perfusion in preparation for gastrointestinal examination (e.g. colonoscopy, barium enema X-ray examination), prior to intravenous pyelograms (IVP) or colonic surgery.

Contraindications

Glycoprep-C should not be used by patients with gastrointestinal obstruction, gastric retention, bowel perforation (frank or suspected), toxic colitis, toxic megacolon, ileus, those with a stoma or whose bodyweight is less than 20 kg.

Precautions

Use with caution in patients with severe ulcerative colitis, impaired renal function, pre-existing electrolyte disturbances, congestive heart failure, diabetics and in the elderly.
Patients with impaired gag reflex; who are unconscious or semi-unconscious; who are prone to regurgitation or aspiration; and particularly those with nasogastric intubation; should be carefully observed during the administration of Glycoprep-C.
Patients with congestive heart failure; pre-existing electrolyte disturbances; kidney disease or impaired renal function; using calcium channel blockers; using diuretics or other medications which may affect electrolyte levels; may need to be monitored.
There have also been reports of skin reactions and rhinorrhoea attributed to macrogol which is contained in Glycoprep-C.
Glycoprep-C may cause bloating, distension or abdominal pain, especially if administered by nasogastric tube. If this develops, the rate of administration should be slowed or temporarily ceased until the symptoms abate.
Impaired renal function See Precautions, above.
Use in the elderly Caution should be exercised in the elderly as dehydration and electrolyte depletion may occur. Elderly patients must receive adequate fluids during administration.
Carcinogenesis, mutagenesis, impairment of fertility No carcinogenic or reproductive studies have been performed.
Use in pregnancy It is not known whether Glycoprep-C can cause fetal harm or affect reproductive capacity. Glycoprep-C should only be used if clearly needed.
Use in children The safety and efficacy in children have not been established.
Instructions to patients Glycoprep-C produces a watery diarrhoea about an hour after the first administration and after four hours should produce a clear discharge. This action cleanses the bowel before examination. It should be prepared and taken according to the directions on the sachet or in the Dosage and Administration section.
The patient should fast for two hours before starting to take Glycoprep-C and only take clear fluids until after the examination.
It is important that the patient follow the recommended dosing schedule.

Interactions

Oral medication taken within one hour of the commencement of the administration of Glycoprep-C may be flushed from the gastrointestinal tract and not absorbed.
Because of the macrogol content of Glycoprep-C, there is a possible reduction in the effect of bacitracin and benzylpenicillin when used in conjunction.

Adverse Effects

Nausea, abdominal fullness and bloating are the most common reactions.
Abdominal cramps, vomiting and anal irritation occur less frequently.
These adverse reactions are usually transient and subside rapidly.

Dosage and Administration

Preparation of solution. Dissolve the contents of each 70 g sachet in 1 L of water using a suitable food grade container; or, dissolve the contents of each 210 g sachet in 3 L of water using a suitable food grade container. These may be chilled if desired.
Usual dosage. Unless otherwise directed by your doctor. 3 L of solution is to be made up for the 210 g sachet and taken, while 1 L should be made up for each 70 g sachet.
For oral use. Glycoprep-C produces a watery diarrhoea which empties and cleanses the bowel before examination or surgery. It should be prepared and taken according to the directions. The onset of diarrhoea is about one hour and should be complete in four hours.
Two average size glasses of the prepared solution (350 mL) every 15 minutes. The recommended dosing intake rate is from 1.2 to 1.8 L/hour. Lavage is complete when the faecal discharge is clear.
No food should be taken for two hours prior to commencing dosing. Only clear drinks or liquids are allowed during the interval between commencing the Glycoprep-C preparation and six hours prior to the examination.
For nasogastric intubation. Infuse the prepared solution at a rate of 20 to 30 mL/minute.

Overdosage

Symptoms. In the event of overdosage, dehydration may ensue.
Treatment. The calcium, potassium, chloride and sodium levels should be carefully monitored, and immediate corrective action should be taken to restore electrolyte balance with appropriate fluid replacements.

Presentation

Powder for reconstitution (dry, white crystalline, lemon flavoured): 70 g, 210 g (sachets).

Storage

Store in a cool dry place below 30°C.

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